Gene information
Official symbol IL37
Official full name interleukin 37
Gene type protein-coding gene
Chromosome2q14.1
Alias symbolFIL1; FIL1Z; FIL1(ZETA); IL-1H4; IL-1RP1; IL-1F7
Previous symbolIL1F7
Gene familyInterleukins
Resources
Entrez Gene 27178
HGNC HGNC:15563
Ensembl ENSG00000125571
Vega OTTHUMG00000131345
UCSC uc002tij.4
GO terms: 25 records
GO Description Category LogP Number of genes Detail
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005149 interleukin-1 receptor binding GO Molecular Functions -3.27830815 5 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032720 negative regulation of tumor necrosis factor production GO Biological Processes -18.6356508 28 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -18.2876323 28 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
tildrakizumab TTD view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
interleukin-37 proteomics inflammation[prognosis (bad)] acute ST elevation myocardial infarction He N et al. Nan Fang Yi Ke Da Xue Xue Bao. 2015
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